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Safe tele-oncology requires systems-level design. A formal policy should define when telehealth is appropriate (e.g., stable patients, lab availability) and when in-person evaluation is required (red flags). Obtain informed consent that outlines privacy, limitations, and contingency planning. Use a secure, HIPAA-compliant platform with identity and location verification each visit to enable emergency services if needed. Build workflows for timely labs, vitals (home BP/temperature logs), and adherence checks; integrate PROs for symptom triggers. Standardize documentation (start/stop times, participants, technical issues) and embed clinical decision support (drug–drug interactions, dose modifications). Establish escalation pathways for urgent assessment (same-day access clinic/ED). Personal devices and texting (Option A) risk privacy breaches. Email-only instructions (Option C) lack real-time assessment. Recording without consent (Option D) violates ethics and often state law. The APRN should train staff, provide patient tech support, audit outcomes (no-show rate, toxicity detection), and iterate the program to maintain equity (interpreters, digital access support).