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Safe handling standards for antineoplastic agents require engineering controls and personal protective equipment. Using a CSTD during preparation and administration reduces aerosolization and surface contamination. Chemotherapy-tested double nitrile gloves (changed at recommended intervals), disposable impermeable gowns, eye/face protection for splash risk, and priming IV tubing with non-drug diluent before connecting to the patient are core elements. Manual needle recapping (Option D) increases needlestick injuries and is contraindicated. Priming with drug (Option A) increases contamination risk. Single vinyl gloves (Option C) are inadequate. The APRN leads development of policies aligned with national standards, ensures staff training/competency, audits compliance (wipe tests, spill drills), and coordinates waste segregation and spill management. Patient/caregiver education on handling body fluids at home after certain drugs also falls within APRN scope. Documentation of exposures and access to post-exposure evaluation supports worker safety culture.