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Robust informed consent ensures ethical, legally sound care and supports patient-centered decision-making. Key elements include the diagnosis and treatment intent (curative vs palliative), proposed regimen (agents, schedule), reasonable alternatives (including no treatment), foreseeable risks—including serious toxicities, late effects, fertility/sexual health issues—expected benefits, and practical considerations (duration, monitoring, potential costs/logistics). It must provide space for patient questions and explicitly state the right to decline or withdraw. Obtaining a mere signature (Option A) without substantive content is inadequate. Documenting “discussed” without detail (Option C) fails legal and accreditation standards. Minimizing risks (Option D) undermines autonomy and can erode trust. APRNs should use plain language, teach-back, multilingual materials, and culturally sensitive approaches; document decisional capacity, consent date/time, and participants. Periodic re-consent is appropriate when regimens change. Embedding standardized consent templates and EHR order sets promotes consistency and safety across the infusion system.