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Acute laryngopharyngeal dysesthesia is a characteristic, non-IgE phenomenon with oxaliplatin—sensations of throat tightening or dyspnea often triggered by cold exposure, usually early in treatment. It is frightening but not true bronchospasm or anaphylaxis. Immediate steps are to stop or slow the infusion, keep the patient warm, and provide warm liquids; symptoms typically abate quickly. For subsequent cycles, avoid cold beverages/exposure for 48–72 hours, and consider prolonging infusion duration to reduce peak levels. True hypersensitivity reactions to oxaliplatin occur later after multiple cycles and present with flushing, hypotension, wheeze, or rash—those require antihistamines, steroids, and potentially desensitization protocols. Routine epinephrine (Option A) is unnecessary absent anaphylaxis. High-dose steroids without addressing cold trigger (Option C) adds little benefit. Switching agents (Option D) sacrifices efficacy without cause. APRNs should educate proactively on cold sensitivity, counsel on neuropathy prevention behaviors, and document the event and planned modifications for team consistency.