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Creatine monohydrate is one of the most researched and effective supplements for improving high-intensity, short-duration performance, such as sprinting and weightlifting. It enhances the ATP-PC system by increasing phosphocreatine stores, allowing for greater ATP resynthesis during explosive efforts. Studies consistently demonstrate creatine’s ability to improve strength, power output, and lean muscle mass. ISSA CPT teaches trainers to understand the science and safe use of supplements, while respecting scope of practice limitations (i.e., not prescribing but educating). Unlike vitamins or omega-3s, which support general health, creatine has direct ergogenic benefits. Glucosamine supports joint health but does not enhance performance. Trainers must also educate clients on potential side effects (e.g., water retention, gastrointestinal discomfort) and emphasize proper hydration. Creatine remains legal, safe for most populations, and widely endorsed in sports science, making it a cornerstone supplement in performance-focused training programs.