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Oral oncolytics have narrow therapeutic windows and complex DDI profiles (acid-reducing agents, CYP3A modulators, QT-prolonging drugs). A reliable system couples rigorous medication reconciliation (including OTCs and supplements) with oncology-specific EHR alerts that are curated to minimize noise yet flag high-risk interactions with actionable alternatives (e.g., H2 blockers with timing adjustments instead of PPIs). Embedding a pharmacist-APRN collaborative protocol ensures expert review at initiation and dose changes, while standardized patient education teaches what to avoid and who to call before new meds. A rapid consult pathway (pharmacy/oncology) resolves urgent questions without delaying therapy. Reliance on memory (Option A) and static handouts (Option D) are unsafe. Disabling alerts (Option C) increases error risk. The APRN also monitors for clinical signals of DDIs (toxicity, loss of efficacy), documents counseling, and measures process outcomes (percent reconciled meds, intercepted interactions) to drive continuous improvement.