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Financial toxicity affects adherence, quality of life, and outcomes. After an initial positive screen, best practice is structured assessment with a validated instrument such as the COmprehensive Score for financial Toxicity (COST) to identify specific drivers—copays, travel, lost wages. APRNs should immediately engage financial navigation and social work to pursue manufacturer patient-assistance programs, foundation grants, transportation resources, and benefits optimization (disability, FMLA). Medication access strategies may include 340B pharmacies, generic substitutions, dose-banding when clinically appropriate, and prior-authorization support. Documenting the plan in the EHR, setting check-ins aligned with treatment cycles, and tracking adherence refills help prevent silent nonadherence. Reassurance alone (Option A) ignores modifiable barriers. A single voucher (Option C) provides short-term relief but fails to address ongoing needs or sustainable solutions. Advising patients to stop therapy (Option D) without exploring alternatives contravenes patient-centered care. Incorporating financial outcomes into quality metrics and providing culturally sensitive education (health literacy, digital access) further reduce disparities and support equitable oncology care.