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Balancing a centrifuge is essential for safety and analytical integrity. Unequal mass distribution causes rotor imbalance, leading to vibration, bearing wear, potential mechanical failure, and—in severe cases—sudden breakage that can generate biohazardous aerosols. Balanced loads (equal volume/opposing positions; similar tube type/density) maintain smooth rotation, protect equipment, and ensure reproducible relative centrifugal force (RCF), which affects separation quality (e.g., gel barrier formation, removal of platelets from plasma). Option A understates the purpose; balanced spins are not about speed but safety and quality. Option C is partially related, but gel stability is a function of proper clotting time, RCF, and temperature; balance is broader. Option D is false; even modern centrifuges require conscientious balancing and cannot compensate for significant asymmetry. Operators must also honor manufacturer-specified RCF/time, close lids before start, allow complete stop before opening, and disinfect after spills or tube breakage. Proper centrifuge technique is a frequent exam topic because errors pose high risk and can invalidate results.