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Comprehensive and Detailed Explanation:

The correct answer is B because guidelines mandate that a patient's blood pressure must be carefully lowered and maintained below 185/110 mmHg prior to the administration of intravenous alteplase to minimize the risk of symptomatic intracerebral hemorrhage. Fast-acting intravenous agents like labetalol, nicardipine, or hydralazine are titrated to achieve this target. Option A is incorrect because infusing alteplase while blood pressure remains above 185/110 mmHg violates safety exclusion criteria. Option C is incorrect because transient hypertension does not rule out thrombolysis as long as it can be successfully controlled below the threshold. Option D is incorrect because sublingual or oral short-acting nifedipine can cause precipitous, unmonitored drops in blood pressure, exacerbating cerebral ischemiawithin the penumbra, and is strictly avoided. SCRN nurses must master rapid blood pressure titration protocols during hyperacute screening.