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In RBC transfusion, type O lacks A and B antigens on red cells, and Rh-negative lacks the D antigen. Therefore, O-negative RBCs present no ABO or Rh antigens likely to be attacked by a recipient’s anti-A, anti-B, or anti-D antibodies, making O-negative the classic “universal donor” for RBCs. Thus any ABO/Rh recipient (A, B, AB, O; Rh+ or Rh−) can receive O-negative cells in urgent or compatible settings—answer D. Note an important distinction: this applies to red cell transfusions; plasma compatibility is reversed because plasma contains antibodies (e.g., AB plasma is the “universal donor” for plasma). Options A–C incorrectly restrict compatibility. TEAS Science often tests ABO logic:

• AB+ = universal recipient for RBCs (has A, B, and Rh antigens; no anti-A/anti-B; tolerates all).

• O− = universal donor for RBCs (no A, B, Rh antigens).

Clinical nuance: whenever possible, crossmatch is performed; O-negative is reserved for emergencies (e.g., trauma) or specific populations (e.g., Rh-negative patients of childbearing potential) to conserve supply.