Challenge Your Exam Readiness With Our Free AOCNP Practice Questions

Prevention data for CIPN are limited, but several randomized and pragmatic studies show benefit from limb cooling (cryotherapy) during taxane infusion, likely by reducing local blood flow and drug delivery to peripheral nerves. Cooling gloves/socks applied shortly before and throughout infusion (and shortly after) have been associated with lower rates of numbness, tingling, and functional impairment, with minimal risk when monitored for frost injury. Exercise programs (aerobic/resistance) may also reduce symptom severity and improve function. Routine calcium/magnesium (Option A) lacks consistent efficacy and is not recommended. High-dose vitamin E (Option C) shows inconsistent or negative results and may interact with therapy. Duloxetine (Option D) is first-line for TREATMENT of painful established CIPN, not prevention. The APRN should educate on proper fit and monitoring of cooling devices, document baseline neuropathy, review comorbid risks (diabetes), and ensure early dose/schedule adjustments for neuropathy progression to preserve function without compromising oncologic outcomes.