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High-reliability oncology care requires consistent, closed-loop communication at transitions. Standardized handoff frameworks (I-PASS or SBAR) reduce errors by structuring Illness severity/Situation, Patient summary, Action lists, Situation awareness/contingency planning, and Synthesis by receiver (read-back). Protected handoff without interruptions ensures attention to critical details (antibiotic timing, cultures, MASCC risk, red flags). Including contingency plans (“If MAP <65, start norepinephrine”; “If fever recurs, obtain second set of cultures”) prevents ambiguity. Ad hoc hallway updates (Option A) and free-text variability (Option C) increase omissions. Omitting pending items (Option D) undermines continuity. APRNs can lead implementation with education, audit/feedback, and EHR templates, aligning with sepsis bundles and institutional policies. Monitor metrics such as time-to-antibiotic, missed abnormal vitals, and readmissions to evaluate impact, and refine the process with team input to sustain gains.