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This presentation is classic for invasive mold sinusitis (often mucormycosis), a rapidly progressive angioinvasive infection in neutropenic or diabetic patients. Early mortality is high without prompt action. First-line therapy is expedited IV liposomal amphotericin B; voriconazole lacks activity against many Mucorales. Aggressive surgical debridement is crucial to remove necrotic tissue and reduce fungal burden; coordinate urgently with ENT and ophthalmology. Reverse predisposing factors: optimize glucose, reduce/stop steroids if possible, and consider G-CSF for marrow recovery. Waiting for biopsy or culture (Option C) delays lifesaving care; obtain tissue but do not withhold therapy. Oral fluconazole (Option D) has no activity against molds and is inappropriate. APRNs should activate sepsis protocols, arrange ICU-level monitoring when indicated, educate families about the need for potentially disfiguring but lifesaving surgery, and document serial exams/photographs to track response, adjusting antifungal therapy based on susceptibility and tolerability.