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Evidence supports regular physical activity during and after cancer treatment to reduce fatigue, improve cardiorespiratory fitness, preserve bone mass, and enhance quality of life. A practical target is ≥150 minutes/week of moderate-intensity aerobic exercise (e.g., brisk walking, cycling) or 75 minutes of vigorous activity, plus strength training involving major muscle groups 2–3 days/week. Begin at tolerated levels and progress gradually; incorporate flexibility and balance. Supervised programs are useful for deconditioning or comorbidities. Resistance training is SAFE for individuals with or at risk for lymphedema when progressed sensibly and paired with compression as advised—contrary to Option A. Bed rest (Option C) worsens fatigue and deconditioning. HIIT-only plans (Option D) are not appropriate for all and may be unrealistic early on. The APRN should screen for contraindications (uncontrolled cardiopulmonary disease, severe anemia), provide referrals to oncology rehab/exercise physiologists, counsel on hydration and foot care (for neuropathy), and document goals in the survivorship care plan with follow-up on adherence and barriers.