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High-alert medications (e.g., insulin, opioids, anticoagulants, concentrated electrolytes) have a heightened risk of causing significant patient harm if used in error. Evidence-based strategies include standardized concentrations, limited access, auxiliary labels/tall-man lettering, and independent double-checks prior to preparation/administration (particularly for IV chemotherapy, insulin infusions, and heparin). Option B is correct: an independent double-check by a second clinician can intercept dose and product errors. Option A (multiple locations) increases selection errors; centralizing or controlling storage with ADC restrictions is preferred. Option C is incorrect—using tall-man lettering (e.g., hydrOXYzine vs hydrALAZINE) helps distinguish look-alike names; removing it would increase risk. Option D is unsafe; concentrated KCl should not be stocked on patient care units outside controlled areas; premixed solutions should be used to reduce compounding/administration errors.