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Comprehensive and Detailed Explanation:

Hemostasis begins within seconds of injury. Platelets adhere to exposed collagen, aggregate, and form a plug; the coagulation cascade generates fibrin that stabilizes the clot. Activated platelets release growth factors (PDGF, TGF-β, EGF) and cytokines that recruit inflammatory cells and initiate the subsequent phases. Collagen remodeling occurs much later. Macrophage-driven angiogenesis belongs to the proliferative phase. Re-epithelialization is also a proliferative event. Understanding the temporal sequence and cellular participants of each phase is foundational knowledge in the Wound Healing Environment domain. It enables the clinician to interpret why certain interventions (e.g., hemostatic agents, early growth-factor delivery) are timed to specific biological windows and why disruption of early hemostasis (anticoagulation, coagulopathy) can impair the entire healing cascade.