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Multiple sclerosis (MS) is a chronic, progressive neurological disorder characterized by demyelination in the central nervous system. Unlike conditions such as spinal cord injury or amputation, which may present with more predictable and stable impairments, MS is notable for its variability and unpredictability. Clients often experience relapsing-remitting patterns of symptoms such as fatigue, weakness, visual disturbances, and cognitive changes. This variability necessitates flexible workplace accommodations, including modified schedules, remote work options, or assistive technology. Rehabilitation counselors must collaborate with clients, employers, and healthcare professionals to design accommodations under the Americans with Disabilities Act (ADA) that support vocational participation while balancing fluctuating health. Beyond physical symptoms, MS often carries psychosocial challenges like anxiety, depression, and uncertainty about disease progression. CRC candidates must understand both the medical aspects of chronic illness and their psychosocial impact to provide holistic, client-centered care.