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Relapse is common in substance use recovery and should be used therapeutically. Begin by assessing immediate safety and medical needs, including withdrawal risk (vital signs, history of severe withdrawal, seizure risk). If no acute risk is present, employ motivational interviewing (MI) to enhance readiness for change through empathic, nonjudgmental exploration of ambivalence, goals, and discrepancies. Conduct a functional analysis of the relapse: high-risk situations, affective states, cognitions, and cues. Then update the relapse-prevention plan with concrete coping strategies (urge surfing, stimulus control), supports (sober contacts, meetings), and contingency plans (early warning signs, crisis steps). Consider pharmacotherapy referral (e.g., naltrexone, acamprosate) and level-of-care adjustments only if indicated by severity, environment, or history. Option A is shaming and non-evidence-based. Option C is punitive and undermines engagement. Option D may be appropriate for severe, unstable cases but skipping assessment violates stepped-care principles. A collaborative MI-informed approach that strengthens skills and supports is the best immediate response.