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A proper clean-catch reduces skin and vaginal flora contamination. Instruct the patient to wash hands, separate the labia, and clean front-to-back with fresh towelettes for each wipe. Begin voiding into the toilet to flush urethral contaminants, then—without stopping the stream—move the container into the flow to collect the midstream portion, taking care not to touch the inside of the lid/cup. During menstruation, visible blood can confound tests (e.g., RBCs, dipstick heme); collection is typically deferred unless specifically ordered. Option B encapsulates best practice. Tampons do not “filter” blood for testing purposes (Option A). Beginning at the first drop (Option C) increases contamination. Mouthwash (Option D) is irrelevant and potentially irritating. Label immediately with two identifiers and time, cap securely, and transport promptly or refrigerate short-term per policy. Clear instruction prevents recollects and false positives—competencies emphasized on certification exams.