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Zinc deficiency classically presents with alopecia, impaired wound healing, dermatitis (often periorificial), dysgeusia, and sometimes diarrhea. Patients on long-term PN are at risk if zinc is under-supplemented or if there are excess losses (e.g., high-output fistulas, diarrhea, burns). Diagnostic support includes low plasma zinc (though it is a negative acute-phase reactant and may fall with inflammation). Copper deficiency is associated with anemia, neutropenia, and neurologic myelopathy; selenium deficiency with cardiomyopathy and skeletal muscle weakness; chromium deficiency with insulin-resistant hyperglycemia and peripheral neuropathy. In PN, zinc is typically dosed around 2.5–5 mg/day in stable adults, with higher doses in patients with significant gastrointestinal losses (e.g., additional 12 mg/L of small-bowel drainage or ostomy output). Correction involves adding adequate zinc to PN and addressing losses; clinical signs often improve over weeks. Monitoring should include trace element panels and inflammatory markers to properly interpret levels.