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Comprehensive and Detailed Explanation:

The correct answer is B because recent major surgery or trauma within the preceding 14 days is classified as a relative contraindication (exclusion criterion) for intravenous alteplase in acute ischemic stroke guidelines. This means the treating team must carefully weigh the risk of surgical site hemorrhage against the severity of the neurological deficit and the potential benefit of thrombolysis. Option A is incorrect because not all recent surgeries are absolute exclusions; minor or remote procedures outside the 14-day window carry lower risks, and severe disabling strokes may warrant treatment after risk stratification. Option C is incorrect because ignoring recent surgical history exposes the patient to life-threatening postoperative hemorrhage. Option D is incorrect because prophylactic plasma transfusions are not standard practice to bypass surgical exclusion criteria. SCRN nurses must expertly navigate complex screening checklists, evaluating both absolute and relative contraindications during high-pressure hyperacute scenarios.