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Comprehensive and Detailed Explanation: According to CRNI® Principles of Practice and Infusion Therapy Standards of Practice, site selection must account for underlying neurovascular structures. The ventral (volar) surface of the wrist contains the radial nerve and associated tendons in close proximity to superficial veins; puncture in this area increases the risk of nerve injury, paresthesia, or complex regional pain syndrome. Preferred sites are generally the dorsal hand or forearm veins that are straight, soft, and away from joints and nerves. The antecubital fossa is avoided for routine short peripheral catheters because of joint motion, risk of arterial puncture, and difficulty maintaining patency. In older adults, fragile skin and loss of subcutaneous tissue require careful assessment, but the dorsum of the hand is not exclusively preferred. The medial forearm near the ulnar nerve is also a higher-risk area. Proper body positioning of the extremity during insertion further reduces mechanical trauma. This knowledge aligns with anatomy-and-physiology content weighted in the Principles of Practice domain and supports safe practice to prevent local complications.