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Occupational exposure management is a core safety objective. Immediate washing with soap and water is the first step after a percutaneous injury; mucous membrane exposures should be flushed with water or saline. Do not “milk” or squeeze the wound aggressively, as this can damage tissue without reducing risk. After initial first aid, the exposure must be reported at once per institutional policy so timely risk assessment and post-exposure prophylaxis (PEP) can be considered (e.g., for hepatitis B, hepatitis C, HIV) based on source status and local guidelines. Documentation includes the incident details, device involved, circumstances, and source patient information when available. The exposed worker should proceed to occupational health or the designated provider for evaluation, baseline labs, counseling, and follow-up testing per protocol. Engineering controls (safety needles), work-practice controls (no two-handed recapping), PPE use, and vaccination (e.g., hepatitis B immunization) are preventive measures. Delaying reporting or continuing to draw compromises timely PEP and violates safety policy. Rapid response protects the worker, supports regulatory compliance, and enhances a culture of safety.