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The U.S. Department of Transportation (DOT) Hazardous Materials Regulations (49 CFR Parts 171–180) is the definitive legal framework for shipping and transporting hazardous materials. These regulations establish classification criteria, labeling, marking, packaging, documentation, and training requirements for any entity engaged in hazardous material transport. CERCLA (A) governs Superfund cleanups, not transportation. RCRA Subtitle C (B) focuses on hazardous waste management from cradle to grave but does not specifically dictate transport details. OSHA’s Hazard Communication Standard (D) pertains to workplace hazard communication, such as Safety Data Sheets and labeling, rather than transport requirements. For CHMM professionals, mastery of DOT regulations is essential, as violations can result in severe penalties, accidents, and reputational damage. Proper shipping papers, placarding, and packaging ensure safety during transport and compliance with federal law. The CHMM exam regularly tests knowledge of these DOT standards, as professionals must demonstrate competency in ensuring safe and legal transport of hazardous materials.